Abstract
Objectives: To describe clinical and paraclinical characteristics and to identify HLA-B alleles of patients with carbamazepine and allopurinol-induced SJS/TEN.
Materials and methods: 32 SJS/TEN patients were enrolled in a cross-sectional descriptive study at two hospitals in Hanoi, Vietnam from Mars 2018 to July 2019. Clinical features and laboratory findings were noted, HLA-B alleles were analyzed by the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) assay and LuminexTM Multiplex Technology.
Results: In the patients with allopurinol-induced SJS/TEN, the mean age and the frequency of male patients were higher than those in the patients with carbamazepine, 58.1 years versus 43.9 years; 93.8% versus 62.5%, respectively, p<0.05. All 13 patients with carbamazepine-induced SJS/TEN carried HLA-B*15:02 alleles, 13 patients with allopurinol-induced SJS/TEN carried HLA-B*58:01 alleles.
Conclusion: these HLA-B alleles may play an important role in the pathogenesis of SJS/TEN due to carbamazepine and allopurinol.
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Published | 28-01-2025 | |
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Issue | No. 61 (2020) | |
Section | Original article | |
DOI | 10.38103/jcmhch.2020.61.16 | |
Keywords | hội chứng Stevens-Johnson, hoại tử thượng bì nhiễm độc, carbamazepin, allopurinol, HLA-B*15:02, HLA-B*58:01 Stevens-Johnson syndrome, toxic epidermal necrolysis, carbamazepine, allopurinol, HLA-B*15:02, HLA-B*58:01 |

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