HLA-B alleles in carbamazepine and allopurinol-induced stevensjohnson syndrome (sjs) and toxic epidermal necrolysis (ten) patients

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Abstract

Objectives: To describe clinical and paraclinical characteristics and to identify HLA-B alleles of patients with carbamazepine and allopurinol-induced SJS/TEN.
Materials and methods: 32 SJS/TEN patients were enrolled in a cross-sectional descriptive study at two hospitals in Hanoi, Vietnam from Mars 2018 to July 2019. Clinical features and laboratory findings were noted, HLA-B alleles were analyzed by the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) assay and LuminexTM Multiplex Technology.
Results: In the patients with allopurinol-induced SJS/TEN, the mean age and the frequency of male patients were higher than those in the patients with carbamazepine, 58.1 years versus 43.9 years; 93.8% versus 62.5%, respectively, p<0.05. All 13 patients with carbamazepine-induced SJS/TEN carried HLA-B*15:02 alleles, 13 patients with allopurinol-induced SJS/TEN carried HLA-B*58:01 alleles.
Conclusion: these HLA-B alleles may play an important role in the pathogenesis of SJS/TEN due to carbamazepine and allopurinol. 

https://doi.org/10.38103/jcmhch.2020.61.16

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Published 28-01-2025
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Issue No. 61 (2020)
Section Original article
DOI 10.38103/jcmhch.2020.61.16
Keywords hội chứng Stevens-Johnson, hoại tử thượng bì nhiễm độc, carbamazepin, allopurinol, HLA-B*15:02, HLA-B*58:01 Stevens-Johnson syndrome, toxic epidermal necrolysis, carbamazepine, allopurinol, HLA-B*15:02, HLA-B*58:01

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Huyen, T. T., Phuong, N. H., & Lan, P. T. (2025). HLA-B alleles in carbamazepine and allopurinol-induced stevensjohnson syndrome (sjs) and toxic epidermal necrolysis (ten) patients. Journal of Clinical Medicine Hue Central Hospital, (61), 108–113. https://doi.org/10.38103/jcmhch.2020.61.16