The results of treatment of stage II-III distal gastric adenocarcinoma

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Abstract

Methods: Prospective study on 58 patients with stage II-III gastric adenocarcinoma, underwent distal gastrectomy and D1 or D2 dissection, completedpostoperative chemoradiation therapy with capecitabine and 4-6 cycles with EOX regimen at Oncology center of Hue central hospital from 2010 to 12/2015.

Results: average age of 55.16 ± 9.1, male/female ratio: 3/1, recurrence was common in the first year after treatment (62.5%), the average time of recurrence and metastasis were 13.50 ± 7.29 months and 18.75 ± 8.97 months, respectively.The mean overall survival was 41.21 ± 21.06 months, the overall survival of 12 months was 98.3%, of 24 months was 77.6% and of 36 months was 63.7%, of 48 months was 58.2% and of 60 months to 90 months was 50.1%.The mean disease free survival was 36.22 ± 22.64 months. The mean overall survival: stage II was 41.88 ± 20.78 months; stage III was 39.59 ± 22.27. The mean overall survival for extention of primary tumors: T3 was 40.79 ± 19.61 months; T4 was 41.33 ± 24.80 months. The mean overall survival for extensive of lymph nodes: N (-) was 41.16 ± 20.51 months, N (+) was 41.26 ± 22.06 months.

References

Nguyễn Bá Đức (2010), “Ung thư dạ dày”, Điều trị nội khoa bệnh ung thư, Nxb Y học, tr.29 - 46, 66 - 74, 127 - 141.

Trịnh Tuấn Dũng (2009), “Nghiên cứu đặc điểm giải phẫu bệnh ung thư dạ dày”, Tạp chí Y học thành phố Hồ Chí Minh, 13(6), tr. 754-759

Trịnh Thị Hoa (2009), “ Đánh giá hiệu quả của hóa trị bổ trợ ECX trên bênh nhân ung thư biểu mô tuyến dạ dày sau phẫu thuật tại bệnh viện K (2006 - 2009)”, Luận văn Thạc sĩ Y học, Trường Đại học Y khoa Hà Nội.

Nguyễn Duy Thăng và CS (2006), “Nghiên cứu dịch tể học mô tả một số bệnh ung thư tại Thừa Thiên Huế giai đoạn 2001-2004”, Tạp chí Y học thực hành, 541, tr. 18-32

Vũ Quang Toản, Đoàn Hữu Nghị, Đỗ Anh Tú (2015), “ Điều trị Ung thư dạ dày tiến triển tại chỗ bằng phẫu thuật và hóa trị bổ trợ phác đồ EOX”, Tạp chí Y học lâm sàng, Số 29 -2015, tr 270- 278.

Lê Thị Huỳnh Trang, Lê Đông Nhật Nam, Bùi Chí Viết (2015), “ Khảo sát liên quan biểu hiện quá mức HER2 với đặc điểm lâm sàng và bệnh học trong carcinom tuyến dạ dày”, Tạp chí Ung thư học Việt Nam, Số 4-2015, tr 204 –210.

Daniel T. Dempsey (2006), “Stomach”, Schwartz’s Manual OfSurgery Eighth Edition, Chapter 25,pp. 650 – 684

E. P. M. Jansen, H. Boot et al (2010), “Postoperative chemoradiotherapy in gastric cancer a phase I–II study of radiotherapy with dose escalation of weekly cisplatin and daily capecitabine chemotherapy”, Annals of Oncology 21: 530-534

F. De Vita, F. Giuliani, M. Orditura (2007), “Adjuvant chemotherapy with epirubicin, leucovorin 5-fluorouracil and etoposide regimen in resected gastric cancer patients: a randomized phase III trial by the Gruppo Oncologico Italia Meridionale (GOIM 9602 Study)”. Annals of Oncology 18: pp 1354–1358

Globocan (IARC) (2012), “Stomach Cancer Estimated Incidence, Mortality and Prevalence Worldwide in 2012”, Section of Cancer Surveillance (21/8/2014).

Jeeyun Lee, Do Hoon Lim, Sung Kim et al (2011), “Phase III Trial Comparing Capecitabine Plus Cisplatin Versus Capecitabine Plus Cisplatin With Concurrent Capecitabine Radiotherapy in Completely Resected Gastric Cancer With D2 Lymph Node Dissection: The ARTIST Trial”, J Clin Oncol, 30, pp. 268-273.

Mattia Falchetto Osti et al (2012),“Adjuvant Chemoradiation with 5-Fluorouracil or Capecitabinein Patients with Gastric Cancer after D2 Nodal Dissection”, Anticancer journal, Chapter 32, pp. 1397-1402.

Mitsuru Sasako (2008), “Surgery and adjuvant chemotherapy”, Int J Clin Oncol, 13, pp. 193 - 195.

Qing Zhang, Jeremy Tey, Lihua Peng (2012), “Adjuvant chemoradiotherapy with or without intraoperative radiotherapy for the treatment of resectable locally advanced gastric adenocarcinoma”, Radiotherapy and Oncology Journal,102, pp. 51-55.

Sup Kim et al (2011), “Retrospective analysis of treatment outcomes after postoperative chemoradiotherapy in advanced gastric cancer”, Radiat Oncol J, 29(4), pp. 252-259.

Published 27-08-2018
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Issue No. 50 (2018)
Section Original article
DOI
Keywords Ung thư biểu mô tuyến dạ dày gastric adenocarcinoma

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Duy, P. C., Ai, N. T., Xuan, N. T., An, D. H., & Dung, N. C. (2018). The results of treatment of stage II-III distal gastric adenocarcinoma. Journal of Clinical Medicine Hue Central Hospital, (50), 32–40. Retrieved from https://jcmhch.com.vn/index.php/home/article/view/1399