Abstract
Background: Sars-CoV-2 has been identified as the cause of acute respiratory infections in Wuhan city, Hubei province, China, and has since spread worldwide. Sars-CoV-2 is capable of aerosol transmission in enclosed, crowded, and poorly ventilated spaces. COVID-19 illness ranges from asymptomatic to mild symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), sepsis, multiple organ failure, and death. This study aims to determine lactate and PCT levels in Covid-19 patients and examine the relationship between lactate and PCT in Covid-19 patients.
Methods: A cross-sectional study was performed on 126 patients diagnosed with Sars-Cov-2 infection by RT-PCR.
Results: Mean age was 55.98 ± 17.1 years (range: 4-98 years). Patients more than 60 years old were accounted for the highest rate (42.8%). Median PCT: 3.6 (95%CI:3.21 - 3.75) ng/ml; median lactate 1.5 (95%CI:1.21 - 1,91) mmol/L; lactate has a positive and weak correlation with procalcitonin with r = 0.241; p < 0.001. Procalcitonin concentration > 0.1 ng/ml; lactate > 2 mmol/l in patients with Covid-19 accounted for a high rate with 89.7% and 39.7%.
Conclusion: Serum level of procalcitonin and lactate raise highly in Covid-19 patients.
References
Xu J-b, Xu C, Zhang R-b, Wu M, Pan C-k, Li X-j, et al. Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China. Scientific reports. 2020. 10: 1-10.
Bộ y tế. Hướng dẫn chẩn đoán và điều trị COVID-19. 4689/QĐ-BYT. 2021.
Heer RS, Mandal AK, Kho J, Szawarski P, Csabi P, Grenshaw D, et al. EXPRESS: elevated procalcitonin levels in severe Covid-19 may not reflect bacterial co-infection. Annals of clinical biochemistry. 2021: 00045632211022380.
Dolci A, Robbiano C, Aloisio E, Chibireva M, Serafini L, Falvella FS, et al. Searching for a role of procalcitonin determination in COVID-19: a study on a selected cohort of hospitalized patients. Clinical Chemistry and Laboratory Medicine (CCLM). 2021. 59: 433-440.
Gok A, Kasapoglu US, Delen LA, Ozmen F, Banazili S. The Lactate/Albumin Ratio As A Prognostic Factor For Short Time Mortality In Critically Ill COVID-19 Patients.
Shen Y, Cheng C, Zheng X, Jin Y, Duan G, Chen M, et al. Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19: A Meta-Analysis Based on 10 Cohort Studies. Medicina. 2021. 57: 594.
Taha SI, Shata AK, Baioumy SA, Fouad SH, Youssef MK. The Clinical Utility of Serial Procalcitonin and Procalcitonin Clearance in Predicting the Outcome of COVID-19 Patients. medRxiv. 2021.
Krause M, Douin DJ, Tran TT, Fernandez-Bustamante A, Aftab M, Bartels K. Association between procalcitonin levels and duration of mechanical ventilation in COVID-19 patients. Plos one. 2020. 15: e0239174.
| Published | 01-01-2022 | |
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| Issue | No. 75 (2022) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.2022.75.8 | |
| Keywords | Covid-19, procalcitonin, lactate. Covid-19, procalcitonin, lactate. |
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