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Abstract
Background: The development of improved diagnostic techniques, increased incidence of long term
survival and life expectancy of cancer patients lead to the higher frequency of multiple primary malignant
neoplasms (MPMN). This article aims to report series of cases our observed trend of increasing, in
prevalence of both synchronously and metachronously second and third primary malignancy. Among the
patients have been diagnosed with a cancer and reviewed in the relevant literature.
Case series: Among 17 cases of MPMN that have been reported, 4/17 were synchronous (23.5%) and
13/17 were metachronous (76.5%), out of 17 patients, 10 were femals and 7 were males. The majority
of the cases were over 60 years of age. In this report, the most common types of cancer were GIST
(Stomach, Small intestine): 4/17 (23.5%); Breast: 6/17 (35.3%), Adenocarcinome of lung and colorectal:
2/17 (11.8%) as the first primary and Adenocarcinoma of gastrointestinal tract: 6/17 (35.3%), lung: 2/17
(11.8%), gynecologic tumors: 5/17 (29.4%), Breast: 2/17 (11.8%), lung: 3/17 (17,6%) as the second or the
third primary cancer.Among 17 such patients, 15 and 2 primary malignant lessions occured at 2 sites and
3 sites respectively. Conclusion: The incidence of MPMN has not been rare at all. The diagnosis of MPMN should not be
overlooked during follow - up. The doctor - patient relationship remains a critical factor in management. The
clinicians should be aware of cases that cancer patients have metastasis in unusual sites and inconsistent
clinical progression.
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| Published | 03-12-2021 | |
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| Issue | No. 74 (2021) | |
| Section | Original article | |
| DOI | ||
| Keywords | Nhiều ung thư, nguyên phát. Multiple malignant neoplasms, primary |
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