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Abstract
Subcutaneous panniculitis - like T - cell lymphoma (SPTCL) is a rare type of lymphoma that mainly
affects the skin and subcutaneous fat tissue. SPTCL can occur in both adults and children. The average
age at diagnosis is 30 years old, with more women than men. In SPTCL, the patient has multiple nodules in
the fat layer under the skin, and these can cause swelling. This is known as panniculitis. The pathogenesis
is unknown, but genetic factors may be involved. Diagnosis of SPTCL is challenging, mainly based
on skin biopsies with staining of immunohistochemical markers. Treatment of SPTCL is inconsistent,
depending on symptoms but usually using steroids or immunosuppressive drugs (ACEIs). Some patients with advanced SPTCL require chemotherapy. In terms of patients who have hemophagocytic
lymphohistiocytosis (HLH), which is less responsive to treatment and has a worse prognosis. We report
a 13 - month - old boy admitted to the hospital with fever and multiple subcutaneous lesions. The patient
was diagnosed with cellulitis and treated with antibiotics for 2 weeks, but the disease did not improve.
Then, the patient had a skin lesion biopsy. Based on the results of immunohistochemical staining, we
concluded that it was suitable for SPTCL.
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| Published | 02-12-2021 | |
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| Issue | No. 74 (2021) | |
| Section | Case report | |
| DOI | 10.38103/jcmhch.2021.74.15 | |
| Keywords | U lympho tế bào T dạng viêm mỡ dưới da, hóa mô miễn dịch, hội chứng thực bào máu. Subcutaneous panniculitis - like T - cell lymphoma, Immunohistochemical, Hemophagocytic lymphohistiocytosis. |
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