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Abstract
Renal cell carcinoma is a rare malignancy, accounting for only 2 - 6% of renal malignancies in children.
Renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion is a subgroup of renal cell
carcinoma, often with a more severe prognosis than other groups of renal cell carcinoma. We report on a 10
- year - old child was admitted to the hospital because of abdominal painand a left kidney tumor. After tumor
resection, histopathological examination, immunohistochemical staining was positive for TFE3, CD10,
negative for CK7, diagnosis renal cell carcinoma associated with Xp11.2 translocation factor E3 gene
fusion. Two weeks after surgery, the patient was stable and discharged from the hospital. Re - examination
after two months did not detect tumor recurrence or metastasis.
References
Kumar S, Sharma P, Pratap J, et al. Renal cell
carcinoma in children and adolescence: our
experience. African journal of paediatric surgery:
AJPS 2014;11:101-4.
Moch H, Cubilla AL, Humphrey PA, Reuter
VE,Ulbright TM. The 2016 WHO Classification
ofTumours of the Urinary System and Male
GenitalOrgans-Part A: Renal, Penile, and
Testicular Tumours. Eur Urol. 2016; 70: 93-105.
James I. Geller, Peter F. Ehrlich, Nicholas G.
Cost, Geetika Khanna, Elizabeth A. Mullen,
Eric J. Gratias.Characterization of Adolescent
and Pediatric Renal Cell Carcinoma, a Report
from the Children’s Oncology Group Study
AREN03B2.
Tsai HL, Chin TW, Chang JW, et al. Renal cell
carcinoma in children and young adults. JCMA
;69:240-4.
Bitar RD, Daw NC. Renal Cell Carcinoma in
Children. In: Rare Kidney Tumors. 2019; 31-41.
Hollingsworth JM, Miller DC, Daignault S, et al.
Rising incidence of small renal masses: a need
to reassess treatment effect. J Natl Cancer Inst
;98:1331-4.
Green, W.M.; Yonescu, R.; Morsberger, L.;
Morris, K.; Netto, G.J.; Epstein, J.I.; Illei, P.B.;
Allaf, M.; Ladanyi, M.; Griffin, C.A.; et al.
Utilization of a TFE3 break-apart FISH assay in
a renal tumor consultation service. Am. J. Surg.
Pathol. 2013, 37, 1150-1163.
Komai Y, Fujiwara M, Fujii Y, et al. Adult Xp11
translocation renal cell carcinoma diagnosed by
cytogenetics and immunohistochemistry. Clin
Cancer Res 2009;15(4):1170-6.
Meyer PN, Clark JI, Flanigan RC, et al. Xp11.2
translocation renal cell carcinoma with very
aggressive course in five adults. Am J Clin
Pathol 2007;128(1):70-9.
Geller JI, Argani P, Adeniran A, et al.
Translocation renal cell carcinoma: lack of
negative impact due to lymph node spread.
Cancer 2008;112(7):1607-16.
Manikandan R, Srinivasan V, Rane A. Which
is the real gold standard for smallvolume
renal carcinoma? Radical nephrectomy
versus nephron-sparing surgery. JEndourol
;18(1):39-44.
Cook A, Lorenzo AJ, Satle JL, et al. Pedatric
renal cell carcinoma: single institution 25-year
case series and initial experience with partial
nephrectomy. J Urol 2006;175(4):1456-60.
Haecker FM, von Schweinitz D, Harms D, et al.
Partial nephrectomy for unilateral Wilms tumor:
results of study SIOP 93-01/GPOH. J Urol
;170(3):939-44.
Rialon KL, Gulack BC, Englum BR, et
al. Factors impacting survival in children
with renal cell carcinoma. J Pediatr Surg
;50(6):1014-8.
Chao Liu, Weiping Zhang, Hongcheng Song.
Nephron - sparing surgery in the treatment of
pediatric renal cell carcinoma associated with
Xp11.2 translocation/TFE3 gene fusions. Journal
of Pediatric Surgery 52 (2017); 1492-1495
| Published | 06-12-2021 | |
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| Issue | No. 74 (2021) | |
| Section | Case report | |
| DOI | ||
| Keywords | Ung thư biểu mô tế bào thận, TFE3/Xp11.2. Renal cell carcinoma, TFE3, Xp11.2 translocation. |
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