Abstract
Background: Extremely preterm infants are the leading cause of morbidity and mortality in the world. This group of newborn has a high mortality rate, with many complications of premature birth. The study aimed to evaluate the rate and etiologies of mortality and find out the morbidity of extremely preterm infants in Hue Central Hospital.
Method: Descriptive study, follow - up, including all extremely preterm infants hospitalized at Neonatal Intensive Care Unit, Hue Central Hospital from 01/01/2022 to 31/12/2022.
Results: 30 infants between 22 - 28 weeks, male/female ratio is 1:1, mortality rate is 50%, in which the ratio of groups 22 - 24 weeks, 25 - 26 weeks, 27 - 28 weeks are respectively 100%, 66,7% and 23,5%. Etiologies of mortality: Respiratory failure, sepsis, pulmonary hemorrhage, intraventricular hemorrhage. Common pathologies of extremely preterm infants are respiratory failure 100%, early onset sepsis 96.7%, late onset sepsis 88%, indirect hyperbilirubinemia 83,3%, acute respiratory distress syndrome 80%, anemia requiring red blood cell transfusion 80%, bronchopulmonary dysplasia 25%, retinopathy requiring treatment 20%, pneumothorax 13.3%.
Conclusion: The mortality rate of extremely preterm infants is 50%. Common etiologies of mortality are respiratory diseases and infections. Common pathologies of extremely premature children are respiratory failure, infections, jaundice, and anemia.
References
Patel R. Short- and Long-Term Outcomes for Extremely Preterm Infants. Amer J Perinatol. 2016;33(03):318-28.
Wu F, Liu G, Feng Z, Tan X, Yang C, Ye X, et al. Short- term outcomes of extremely preterm infants at discharge: a multicenter study from Guangdong province during 2008- 2017. BMC Pediatr. 2019;19(1):405.
Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network. Pediatrics. 2010;126(3):443-56.
Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, et al. Validation of the National Institutes of Health Consensus Definition of Bronchopulmonary Dysplasia. Pediatrics. 2005;116(6):1353-60.
Özek E, Kersin SG. Intraventricular hemorrhage in preterm babies. Turk Pediatri Ars. 2020;55(3):215-21.
Zhang WW. Treatment status of extremely premature infants with gestational age < 28 weeks in a Chinese perinatal center from 2010 to 2019. World Journal of Pediatrics. 2022.
Tran KH, Vo-Van NL, Nguyen-Thi KH, Le-Thi PA, Nguyen HS. Neonatal Morbidity and Mortality in a Neonatal Unit in a Vietnamese Hospital. IJN. 2022;13(2).
Bell EF, Hintz SR, Hansen NI, Bann CM, Wyckoff MH, DeMauro SB, et al. Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013-2018. JAMA. 2022;327(3):248.
EPIPAGE 2 Writing Group, Ancel PY, Goffinet F. EPIPAGE 2: a preterm birth cohort in France in 2011. BMC Pediatr. 2014;14(1):97.
Boghossian NS, Geraci M, Edwards EM, Horbar JD. Sex Differences in Mortality and Morbidity of Infants Born at Less Than 30 Weeks’ Gestation. 2018;142(6).
Hoàng Nguyệt Quỳnh, Nguyễn Thị Cự, Hoàng Mai Linh, Nguyễn Thị Thảo Trinh. Nghiên cứu đặc điểm sơ sinh cân nặng dưới 1500 gram tại Trung tâm Nhi - Bệnh viện Trung ương Huế. Tạp chí Y Dược Học - Trường Đại học Y Dược Huế. 2023;13(3):66-72.
Jacob J, Kamitsuka M, Clark RH, Kelleher AS, Spitzer AR. Etiologies of NICU Deaths. 2015;135(1).
Lê Nguyễn Nhật Trung, Lê Thị Thuỳ Dung, Trần Trọng Phương Trừ. Kết quả điều trị trẻ sơ sinh non 26 - 34 tuần tuổi thai Tại Bệnh Viện Nhi Đồng 2. Y học TP Hồ Chí Minh. 2016;20(2):30-6.
Acun C, Nusairat L, Kadri A, Nusairat A, Yeaney N, Abu J, et al. Pneumothorax prevalence and mortality per gestational age in the newborn. Pediatric Pulmonology. 2021;56(8):2583-8.
Marques BR, Dinis AC, Rocha G, Flôr-de-Lima F, Matos AC, Henriques C, et al. Morbidity and mortality in preterm infants less than 29 weeks of gestational age. Open Access. 2019;8(1).
Published | 15-04-2024 | |
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Issue | No. 96 (2024) | |
Section | Original article | |
DOI | 10.38103/jcmhch.96.2 | |
Keywords | Sơ sinh cực non, cân nặng rất thấp, bệnh lý, tử vong Extremely preterm infants, very low birth weight, morbidity, mortality |

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