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Abstract
Background: Metabolic syndrome (MetS) is characterized by abdominal obesity, dyslipidemia, hypertension, glucose intolerance and is associated with an increased risk of developing cardiovascular disease, diabetes mellitus and related diseases. Elevated levels of high-sensitivity C-reactive protein (hsCRP) are associated with an increased waist circumference, insulin resistance, body mass index (BMI) and hyperglycemia and are increased with the number of the MetS components. Plasma hs-CRP levels independently predicted the occurrence of future cardiovascular disease events and may be an important independent predictor of unfavourable outcomes in the MetS.
Objective: Find out what risk factors for metabolic syndrome were associated with increased plasma
hs-CRP levels.
Material and method: A cross sectional study with control group on 303 adult subjects for health examinations at International Medical Center at Hue Central Hospital, including 108 subjects with metabolic syndrome and control group of 195 subjects without metabolic syndrome Metabolic syndrome was defined according to the IDF, NHLBI, AHA, WHF, IAS, IASO (2009). Anthropometric factors and biochemical parameters (hs-CRP, total cholesterol, triglycerides, HDL-L, LDL-C, fasting blood glucose and HbA1C) were determined. Univariate and multivariate analyses were conducted to evaluate the association of hs-CRP and MetS.
Results: BMI, waist circumference, HbA1C, HDL-C, systolic blood pressure and MetS were associated with increased plasma hs-CRP levels (p <0,05 to p <0,001). In particular, HbA1C, HDL-C and systolic blood pressure were independent risk factors for increasing plasma hs-CRP levels (p <0,05 to p <0,001).
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| Published | 18-01-2025 | |
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| Issue | No. 61 (2020) | |
| Section | Original article | |
| DOI | 10.38103/jcmhch.2020.61.7 | |
| Keywords | Hội chứng chuyển hóa, protein phản ứng C độ nhạy cao Metabolic syndrome, high-sensitivity C-reactive protein |
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