Tải xuống
Tóm tắt
ABSTRACT
Background: Hue Central Hospital (HCH) plays a key role intreating Acute Myeloid Leukemia (AML) in the central zone of Vietnam which covers geographically vast areas. Before 2010, all the AML patients died, and abandonment rate was more than 50%. The aims of this study are to determine the outcome of newly diagnosed children with AML treated at HCH from 2010 to 2018.
Methods: This is a retrospective review of 98 children with AML admitted from January 2010 to December 2018. The diagnosis was confirmed by morphological FAB criteria, cytochemistry and immunophenotype. Patients were treated with using modified AML 7-3 Regimen. Social supports were provided to patients/families.
Results: A total of 98 children with AML were analyzed with median age of 5,6 years ranging from 3 months to 15 years. The male to female ratio was 1,8:1. The overall complete remission (CR) rate on day 21 of induction were 62.2%. 46 patients (46.9%) appeared relapse, in which 27 patients had relapse during the time they recured chemotherapy, 19.4% after finishing chemotherapy. Overall survival (OS) at 8 years were 23.2%. The event-free survival (EFS) at 8 years were 20.2%. Abandonment cases were 4 (4.1%).
Conclusion: With less toxic modified protocol, survival rate has been improved and treatment related mortality was minimized though high relapse rate is still an issue. Abandonment has been reduced successfully with holistic strategies such as financial support, managing family group, providing education, early follow-up of patients who missed appointments and free accommodation near hospital for patients/families.
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| Đã xuất bản | 24-01-2025 | |
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| Số tạp chí | Số 56 (2019) | |
| Phân mục | Nghiên cứu | |
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