Tóm tắt
Aims: To determine the serum TNF-α concentration and arterial age of patients with acute cerebral infarction; and explore the relationship between serum TNF-α concentration and arterial age with age, gender, smoking history, blood pressure, blood lipid profile, diabetes, ejection fraction, carotid atherosclerosis in patients with acute cerebral infarction.
Methods: A cross-sectional descriptive study was conducted on patients with acute cerebral infarction at the Department of Intensive Care and Stroke - Hue Central Hospital from May 2023 to June 2024. Clinical and paraclinical results were used to analyze factors related to TNF-α.
Results: The average TNF-α concentration was 23.81 ± 9.11 (pg/mL). Patients with arterial age (76.37 ± 8.05) were greater than actual age (68.63 ± 12.32) significantly (p < 0.001). There was a correlation between smoking, hypertension, diabetes, ejection fraction (EF), carotid atherosclerosis and arterial age with TNF-α.
Conclusion: In patients with acute cerebral infarction, TNF-α concentration was increased. Arterial age was greater than the actual age of the patient.
Tài liệu tham khảo
Vinh Hiep Do, Nguyen Dang Thi. Study on the relationship between clinical and brain CT images in patients with acute stroke. Vietnam Medical Journal. 2021;498(1):1-5.
Tran V, Van Bang L, Hoang T. Study of Hs-CRP and TNF-a levels in copd patients accompanied with coronary artery disease. Journal of Medicine and Pharmacy. 2014:48-56.
Flores-Cantú H, Góngora-Rivera F, Lavalle-González F, Villarreal-Pérez JZ, Cantú-Sánchez D, Anaya-Escamilla A, et al. Tumor Necrosis Factor alpha, prognosis and stroke subtype etiology. Medicina Universitaria. 2016;18(73):194-200.
Maas MB, Furie KL. Molecular biomarkers in stroke diagnosis and prognosis. Biomark Med. 2009;3(4):363-383.
Yang Y, Wang A, Yuan X, Zhao Q, Liu X, Chen S, et al. Association between healthy vascular aging and the risk of the first stroke in a community-based Chinese cohort. Aging (Albany NY). 2019;11(15):5807-5816.
Elfiky AM, Ahmed Mahmoud A, Zeidan HM, Mostafa Soliman M. Association between circulating microRNA-126 expression level and tumour necrosis factor alpha in healthy smokers. Biomarkers. 2019;24(5):469-477.
Mehaffey E, Majid DSA. Tumor necrosis factor-α, kidney function, and hypertension. Am J Physiol Renal Physiol. 2017;313(4):F1005-f1008.
Desai RJ, Solomon DH, Schneeweiss S, Danaei G, Liao KP, Kim SC. Tumor Necrosis Factor-α Inhibitor Use and the Risk of Incident Hypertension in Patients with Rheumatoid Arthritis. Epidemiology. 2016;27(3):414-22.
Cheng Y, An B, Jiang M, Xin Y, Xuan S. Association of Tumor Necrosis Factor-alpha Polymorphisms and Risk of Coronary Artery Disease in Patients With Non-alcoholic Fatty Liver Disease. Hepat Mon. 2015;15(3):e26818.
Akash MSH, Rehman K, Liaqat A. Tumor Necrosis FactorAlpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus. J Cell Biochem. 2018;119(1):105-110.
Boulogne M, Sadoune M, Launay JM, Baudet M, CohenSolal A, Logeart D. Inflammation versus mechanical stretch biomarkers over time in acutely decompensated heart failure with reduced ejection fraction. Int J Cardiol. 2017;226:53-59.
Tay C, Liu YH, Hosseini H, Kanellakis P, Cao A, Peter K, et al. B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation. Cardiovasc Res. 2016;111(4):385-97.
Lu L, Zhang RY, Wang XQ, Liu ZH, Shen Y, Ding FH, et al. C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis. Eur Heart J. 2016;37(22):1762-71.
Tesauro M, Mauriello A, Rovella V, AnnicchiaricoPetruzzelli M, Cardillo C, Melino G, et al. Arterial ageing: from endothelial dysfunction to vascular calcification. J Intern Med. 2017;281(5):471-482.
Harvey A, Montezano AC, Touyz RM. Vascular biology of ageing-Implications in hypertension. J Mol Cell Cardiol. 2015;83:112-21.
Đã xuất bản | 19-11-2024 | |
Toàn văn |
|
|
Ngôn ngữ |
|
|
Số tạp chí | Tập 16 Số 8 (2024) | |
Phân mục | Nghiên cứu | |
DOI | 10.38103/jcmhch.16.8.4 | |
Từ khóa | Cerebral infarction, TNF-α. arterial age |

công trình này được cấp phép theo Creative Commons Attribution-phi thương mại-NoDerivatives 4.0 License International . p>
Bản quyền (c) 2024 Tạp chí Y học lâm sàng Bệnh viện Trung Ương Huế