Clinical characteristics and treatment outcomes of skin and soft tissue infections in children: a prospective study

Tải xuống

Dữ liệu tải xuống chưa có sẵn.

Phiên bản

pdf (English)     27    8

Tóm tắt

Backgroundː This study addresses the elevated prevalence of skin and soft tissue infections (SSTIs) within the pediatric demographic, necessitating a comprehensive inquiry into their varied clinical manifestations. The primary objectives involve the assessment of clinical and laboratory characteristics of SSTIs in children and an exploration of their correlation with treatment efficacy.

 

Methodsː From April 2022 to June 2023, a prospective observational study was conducted on 87 pediatric bacterial SSTI cases at a Tertiary Paediatric Centre in Central Vietnam.

 

Resultsː SSTIs were most common in children ages 1-4, 48.3%. Seasonal trends showed a peak incidence in summer (43.7%). In 93.1% of patients, febrile presentation and edema predominated. About 40.2% of people had lower extremity involvement. Analysis showed significant rates of severe (73.6%) and purulent (67.8%) SSTIs. Leukocytosis was found in 39.1% of patients, mostly due to 72.4% increased CRP. Even though only 2.4% of blood cultures were positive, Staphylococcus aureus caused 76.9% of infections. About 42.5% of patients had shorter treatments. Significantly, purulent SSTIs required longer antibiotic therapy than nonpurulent infections (p < 0.05). 27.6% of children needed surgery, and most received intravenous antibiotics. Most importantly, all patients recovered.

 

Conclusionsː Predominantly observed among pediatric cases were purulent SSTIs, exhibiting a proclivity for the lower limbs, with Staphylococcus aureus as the predominant etiological agent. Treatment duration for purulent SSTIs exceeded that for nonpurulent infections. Intravenous antibiotic administration emerged as the predominant therapeutic modality, yielding favorable outcomes.

https://doi.org/10.38103/jcmhch.95.4

Tài liệu tham khảo

Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, Goldstein EJ, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clinical Infectious Diseases. 2005;41(10):1373-1406.

Lopez MA, Cruz AT, Kowalkowski MA, Raphael JL. Trends in resource utilization for hospitalized children with skin and soft tissue infections. Pediatrics. 2013;131(3):e718-e725.

Sari MK, Satria CD, Arguni E. Predictors of Infection in Children with Systemic Lupus Erythematosus: A Single Center Study in Indonesia. Global Pediatric Health. 2021;8:2333794X211005609.

Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: a review of their epidemiology, pathogenesis, diagnosis, treatment and site of care. Canadian Journal of Infectious Diseases Medical Microbiology. 2008;19:173-184.

Dryden MS. Skin and soft tissue infection: microbiology and epidemiology. International journal of antimicrobial agents. 2009;34:S2-S7.

Demling RH, Waterhouse B. The increasing problem of wound bacterial burden and infection in acute and chronic soft-tissue wounds caused by methicillinresistant Staphylococcus aureus. Journal of burns wounds. 2007;7:e8.

Maltezou HC, Katerelos P, Asimaki H, Roilides E, Theodoridou M. Antibiotic prescription practices for common infections and knowledge about antibiotic costs by private-practice pediatricians in Greece. Minerva Pediatr. 2014;66(3):209-16.

Rath E, Skrede S, Oppegaard O, Bruun T. Non-purulent skin and soft tissue infections: predictive power of a severity score and the appropriateness of treatment in a prospective cohort. Infect Dis (Lond). 2020;52(5):361-371.

Sunderkötter C, Becker K. Frequent bacterial skin and soft tissue infections: diagnostic signs and treatment. J Dtsch Dermatol Ges. 2015;13(6):501-24; quiz 525-6.

Fenster DB, Renny MH, Ng C, Roskind CG. Scratching the surface: a review of skin and soft tissue infections in children. Curr Opin Pediatr. 2015;27(3):303-7.

Hurley HJ, Knepper BC, Price CS, Mehler PS, Burman WJ, Jenkins TC. Avoidable antibiotic exposure for uncomplicated skin and soft tissue infections in the ambulatory care setting. Am J Med. 2013; 126(12): 1099-106.

Papastefan ST, Buonpane C, Ares G, Benyamen B, Helenowski I, Hunter CJ. Impact of Decolonization Protocols and Recurrence in Pediatric MRSA Skin and Soft-Tissue Infections. J Surg Res. 2019;242:70-77.

Đã xuất bản 20-05-2024 — Cập nhật lúc 10-05-2024
Toàn văn
pdf (English)     27    8
Ngôn ngữ
Số tạp chí Số 95 (2024)
Phân mục Nghiên cứu
DOI 10.38103/jcmhch.95.4
Từ khóa Skin Diseases, Infectious, Child, Vietnam, Anti-Bacterial Agents Skin Diseases, Infectious, Child, Vietnam, Anti-Bacterial Agents

Creative Commons License

công trình này được cấp phép theo Creative Commons Attribution-phi thương mại-NoDerivatives 4.0 License International .

Bản quyền (c) 2024 Tạp chí Y học lâm sàng Bệnh viện Trung Ương Huế

Nguyen, H. C. D., Cao, T. N., & Nguyen, V. T. (2024). Clinical characteristics and treatment outcomes of skin and soft tissue infections in children: a prospective study. Tạp Chí Y học lâm sàng Bệnh viện Trung Ương Huế, (95), 28–32. https://doi.org/10.38103/jcmhch.95.4 (Original work published 20 Tháng Năm 2024)