Abstract
The CYP2D6 gene is a member of the cytochrome p450 superfamily.
Objectives: Study on the polymorphism G4268C of CYP2D6 gene in patients with lung cancer in comparision with those in control group.
Methods: Study is carried out on 225 samples of lung cancer patients and 200 control samples. The polymorphism G4268C of CYP2D6 gene was determined by PCR-RFLP (PCR-Restriction fragment length polymorphism).
Results: The non-C4268/C (GG, GC) in lung cancer patients with OR=3.25 (95% Cl=1.08−3.65) compared with the control group CC gennotype. Especially GC genotype in lung cancer patients with OR =4.15 (95% Cl=1.27−5.94) compared with the control group CC gennotype, as well as in patients with adenocarcinoma lung cancer, the non-C4268/C (GG, GC) with OR=2.79 (95% Cl=1.25−4.95) compared with the control group CC gennotype, the non-C4268/C (GG, GC) of lung cancer patients have smoke OR =1.6 (95% Cl=1:15 to 2:35) compared with the group CC gennotype who dit not smoke.
Conclusion: There is a correlation between polymorphism G4268C of CYP2D6 gene with lung cancer as well as their risk factor which is smoking in Vietnam.
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| Published | 07-09-2015 | |
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| Issue | No. 30 (2015) | |
| Section | Original article | |
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| Keywords | Ung thư phổi, đa hình G4268C, gen CYP2D6 lung cancer, polymorphism G4268C, CYP2D6 gene |
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