Tóm tắt
The patient, a 22-year-old female, was diagnosed with diffuse large B-cell lymphoma (an aggressive non-Hodgkin’s lymphoma). The patient completed 6 cycles of R-CHOP (from March 2018 to July 2018). After that, she was re-examined regularly every month (manifested with moderate and hypochromic anemia; bone marrow aspiration was negative for malignancy). In November 2019, the complete blood cell (CBC) findings were as follows: White blood cell (WBC) count 81 x 10^9/liter, neutrophils 7%, lymphocytes 22%, monocytes 2%, blasts 69%; red blood cell count 2.6 x 10^6/ml, hemoglobin 7.8 g/dl, platelet count 192,000. Bone marrow (BM) aspiration: acute myeloid leukemia (AML5?) (81% blasts in BM); blast cells were positive for PAS, myeloperoxidase (MPO), and Sudan black negative. The bone marrow biopsy showed myeloid malignant proliferation. Cluster of Differentiation (CD): positive for CD13, CD33, CD64, HLA-DR; negative for CD11b, CD35, CD71, CD15, CD19, CD20, CD7, CD3, CD38; monoblasts composed 90% of bone marrow cells.
Tài liệu tham khảo
Bhatia S. Therapy-related myelodysplasia and acute myeloid leukemia. Semin Oncol. 2013; 40: 666 - 75.
Godley LA, Larson RA. Therapy-related myeloid leukemia. Semin Oncol. 2008; 35: 418 - 29.
Gong X, Yan L, Xiao X, Tang Q, Zhao X. Secondary mixed phenotype acute leukemia following chemotherapy for diffuse large B-cell lymphoma: a case report and review of the literature. Int J Clin Exp Pathol. 2018; 11: 3104 - 3110.
Delwail V, Jais JP, Colonna P, Andrieu JM. Fifteen-year secondary leukemia risk observed in 761 patients with Hodgkin’s disease prospectively treated by MOPP or ABVD chemotherapy plus high-dose irradiation. Br J Haematol. 2002; 118: 189 - 94.
Sun J, Qu L, Guo Z, Hu G, Xu W. Treatment-related acute myeloid leukemia with type D CBFB-MYH11 after chemotherapy and radiotherapy in non-Hodgkin lymphoma: a rare case report. Int J Clin Exp Med. 2016; 9: 403 - 407.
Yang D, Fu X, Zhang X, Li W, Zhang M. Therapy-related acute myeloid leukemia in patients with lymphoma: A report of four cases and review of the literature. Oncol Lett. 2015; 10: 3261 - 3265.
| Đã xuất bản | 20-06-2020 | |
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| Số tạp chí | Số 62 (2020) | |
| Phân mục | Báo cáo trường hợp | |
| DOI | 10.38103/jcmhch.2020.62.10 | |
| Từ khóa | Non-Hodgkin’s Lymphoma, t-AML. Non-Hodgkin’s Lymphoma, t-AML. |
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