Evaluating the multi-dose intramuscular administration of Methotrexate in the early stage of interstitial ectopic pregnancy

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Background: Interstitial ectopic pregnancy (IEP) occurs when implantation happens in the interstitial part of the fallopian tubes, accounting for 3% of all ectopic pregnancies. This condition poses challenges for surgical intervention due to the difficulty in locating the gestational mass. This study aims to assess the efficacy of multi-dose intramuscular injection of methotrexate (MTX) in treating IEP in the early stages.

Methods: A cross-sectional study was conducted at Hanoi Obstetrics and Gynaecology Hospital from January 2018 to July 2019. Patients were treated with intramuscular MTX injections at a dosage of 1 mg/kg/24 hours on the first day, with subsequent doses adjusted based on βhCG concentration. A total of four MTX injections were administered.

Results: Among 26 eligible patients, the successful treatment rate was 84.62%. βhCG levels significantly decreased after the third injection.

Conclusion: Multi-dose intramuscular MTX injection is an effective and safe treatment option for interstitial ectopic pregnancies in the early stages.

https://doi.org/10.38103/jcmhch.78.9

Tài liệu tham khảo

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Đã xuất bản 23-02-2025
Toàn văn
Ngôn ngữ
Số tạp chí Số 78 (2022)
Phân mục Nghiên cứu
DOI 10.38103/jcmhch.78.9
Từ khóa Interstitial ectopic pregnancy (IEP), medical treatment Interstitial ectopic pregnancy (IEP), medical treatment

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Bản quyền (c) 2022 Tạp chí Y học lâm sàng Bệnh viện Trung Ương Huế

Dao, L. T. A. (2025). Evaluating the multi-dose intramuscular administration of Methotrexate in the early stage of interstitial ectopic pregnancy . Tạp Chí Y học lâm sàng Bệnh viện Trung Ương Huế, (78). https://doi.org/10.38103/jcmhch.78.9