Tải xuống
Tóm tắt
Objective: To study clinical and laboratory features and evaluate the outcome of treatment, to determine the recovery of peripheral blood cells and bone marrow cells after induction treatment of acute lymphoblastic leukemia (ALL) in children.
Method: A descriptive and retrospective study on 39 children diagnosed with ALL and treated in Pediatric Center, Hue Central Hospital from January 2012 to June 2015.
Results: The average age was 48 months old, mostly in the age group 12-60 months old (53.8%). Male /female ratio was 3.3/1.
Clinical features: the rate of fever was 58.9%, the rate of fever with infectious sites was 33.3%. The rate of anemia was 92.3% (severe anemia: 23.1%, moderate anemia: 43.6%, mild anemia: 25.6%). The rate of mild and moderate hemorrhage was 48.7%. The rate of extramedullary infiltration was as follows: hepatomegaly: 87.2%, splenomegaly: 66.7%, enlarged lymph nodes: 33.3%.
Laboratory features: the number of bone marrow cells >100x109/mm³: 51.3%, blast 58.5 ±15.53%. Lympho B: 84.4%, Lympho T: 15.6%.
Outcome: Complete remission: 89.7%, partial remission: 2.6%, death: 7.7%. There was a severe decrease in white blood cells from day 0 to day 7 and day 14 and the recovery was achieved from day 21 to day 28; The rate of severe decrease in neutrophils to less than 1x109/mm³ in the first two weeks was 89.2%, the recovery was achieved at 2.03x109/mm³ in day 28; the number of platelets was decreased in the first-two weeks and achieved at 246x109/mm³ in day 28.
Conclusions: After induction therapy: The rate of complete remission was rather high, mostly the number of peripheral blood cells decreased severely in the first-two weeks and recovered in 4 weeks.
Tài liệu tham khảo
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| Đã xuất bản | 19-08-2016 | |
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| Số tạp chí | Số 36 (2016) | |
| Phân mục | Nghiên cứu | |
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| Từ khóa | Acute lymphoblastic leukemia, induction stage Acute lymphoblastic leukemia, induction stage |
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