Tải xuống
Tóm tắt
Acute Lymphocytic leukemia (ALL) is the most common cancer in children. Cytogenetics analysis plays an important role in classification and prognosis in ALL patient.
Objectives: to define the frequency of chromosomal abnormalities of ALL patients in children.
Methods: 139 patients were diagnosed with ALL at National Children’s Hospital- Hanoi- Vietnam from January/2107 to June/2018. Karyotype analysis and Fluorescence hybridization (FISH) techniques were applied to detect chromosomal abnormalities.
Results: The proportion of male children is higher than that of females, at the age group of 1-10 years, accounting for 86.33%. Immune type predominant group prescursor B (preB) accounted for 92.09%. The frequency of cytogenetic abnormalities, including numerical and/or structural changes, was 36.70%.
Conclusion: Normal karyotype was more frequent in our study. The frequencies of some cytogenetic abnormalities such as t(9;22), t(1;19), MLL- rearranged in our study were comparable to those reported in the literature.
Tài liệu tham khảo
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| Đã xuất bản | 16-01-2025 | |
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| Số tạp chí | Số 51 (2018) | |
| Phân mục | Nghiên cứu | |
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